If you have an expertise in network meta-analysis? Your input is needed to Compare the Efficacy and Safety of Liraglutide, Semaglutide, and Tirzepatide in adults with overweight/obesity but without diabetes
Skills / interests: Risk of Bias assessment, Statistical analysis, Clinical peer review, PICO annotation, Data extraction, Guideline development, Screening and selecting studies, Methodological peer review, Using GRADE, Advocacy, Summary of Findings tables, Training or mentoring, Data analysis and organisation
Methodological skills / interests: GRADEing, Bias, Statistics, Economics, Adverse effects, Comparing multiple interventions (network meta-analysis and overviews)
Dear [Cochrane Collaborator/Expert],
I hope this message finds you well. My name is Wael, and I recently completed my MSc in Endocrinology. Currently, I am working on a network meta-analysis that compares the effectiveness of Liraglutide, Semaglutide, and Tirzepatide in individuals with obesity/overweight but without diabetes. I conducted this analysis as part of the requirements for my MSc and am now reaching out to seek your expertise to make significant revisions before submitting it for publication.
Background:
In the initial stages, my research did not specifically target Cochrane, and I focused on literature searches in MEDLINE and EMBASE. Recognizing the importance of a more comprehensive approach, I am now eager to extend the search to the Cochrane Database for a more thorough analysis.
Literature Search:
I kindly request your guidance on refining the search strategy and identifying relevant studies within the Cochrane Database to complement the information obtained from MEDLINE and EMBASE.
Data Extraction:
During the data extraction step, I encountered challenges understanding the differences between treatment regimen estimand and in-trial estimand tables. I am uncertain about which table is more suitable for data extraction and would greatly appreciate your insights on this matter.
Risk of Bias Assessment:
The risk of bias assessment is a critical aspect of my project that I believe requires substantial revision to enhance its robustness. I seek your expertise to ensure a comprehensive and accurate evaluation of study quality.
Network Meta-Analysis:
Acknowledging the complexities associated with network meta-analysis, I initially conducted a subgroup pairwise meta-analysis due to time constraints. However, I am now keen to transition to a full network meta-analysis and require your support in navigating the assumptions, ranking, and robustness of evidence synthesis.
Timeline:
I am committed to completing the revisions within a month as I recently delved into the study of network meta-analysis. I am a hard worker and am keen to publish within this timeframe to maintain the novelty factor.
Your expertise is highly valued, and I am eager to collaborate with you to ensure the success of this project. Your availability for a discussion or any written guidance would be immensely beneficial.
Thank you for considering my request, and I am hopeful for the opportunity to benefit from your expertise.
Best Regards,
Wael
MSc in Endocrinology